A case of bisphosphonate-related osteonecrosis of the jaw with a particularly unfavourable course: a case report
Viviano Massimo, Addamo Alessandra, Cocca Serena,
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( Viviano Massimo ) - Dentistry Clinic Department of Medical Biotechnologies
( Addamo Alessandra ) - Dentistry Clinic Department of Medical Biotechnologies
( Cocca Serena ) - University of Siena Department of Medicine, Surgery and Neuroscience
Abstract
AbstractBisphosphonates are drugs used to treat osteoclast-mediated bone resorption, including osteoporosis, Paget disease, multiple myeloma, cancer-related osteolysis, and malignant hypercalcemia. The use of these drugs has increased in recent years as have their complications, especially bisphosphonate-related osteonecrosis of the jaw (BRONJ), which more frequently affects the mandible. Here we report a case of BRONJ with a particularly unfavorable course due to cervical inflammation that developed into necrotizing fasciitis, followed by multiorgan involvement leading to septic shock and death.
키워드
Bisphosphonate-associated osteonecrosis of the jaw; Sepsis; Necrotizing fasciitis; Jaw fractures
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